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Histamine trifluoromethyl toluidide : ウィキペディア英語版
Histamine trifluoromethyl toluidide

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Histamine trifluoromethyl toluidide (HTMT) is a mixed H1/H2 histamine agonist which is significantly more potent than histamine itself.〔Whyment AD, Blanks AM, Lee K, Renaud LP, Spanswick D. Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. ''Journal of Neurophysiology''. 2006 Apr;95(4):2492-500. PMID 16354729〕
It also produces additional actions which appear to be independent of histamine receptors.〔Qiu R, Melmon KL, Khan MM. Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. ''Journal of Pharmacology and Experimental Therapeutics''. 1990 Jun;253(3):1245-52. PMID 2359026〕〔Kim DC, Lee SY, Jun DJ, Kim SH, Lee JH, Hur EM, Baek NI, Kim KT. Inhibition of store-operated calcium entry-mediated superoxide generation by histamine trifluoromethyltoluide independent of histamine receptors. ''Biochemical Pharmacology''. 2005 Nov 25;70(11):1613-22. PMID 16219299〕
== References ==



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